The protein encoded by this gene is the CD3-epsilon polypeptide , which together with CD3-gamma , -delta and -zeta , and the T-cell receptor alpha/beta and gamma/delta heterodimers , forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon , gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq , Jul 2008] ,
展开内容
功能:
Function:The CD3 complex mediates signal transduction. ,online information:CD3E mutation db ,similarity:Contains 1 Ig-like (immunoglobulin-like) domain. ,similarity:Contains 1 ITAM domain. ,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma , delta , epsilon , zeta , and eta. ,
Organismal Systems >> Immune system >>Hematopoietic cell lineageOrganismal Systems >> Immune system >>T cell receptor signaling pathwayOrganismal Systems >> Immune system >>Th1 and Th2 cell differentiationOrganismal Systems >> Immune system >>Th17 cell differentiationHuman Diseases >> Cancer: overview >>PD-L1 expression and PD-1 checkpoint pathway in cancerHuman Diseases >> Immune disease >>Primary immunodeficiency
